Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer.

@article{Kim2010MultidrugEP,
  title={Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer.},
  author={Hong-suk Kim and Daniel Nagore and Hiroshi Nikaido},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 5},
  pages={1377-86}
}
RND (resistance-nodulation-division) family transporters in Gram-negative bacteria frequently pump out a wide range of inhibitors and often contribute to multidrug resistance to antibiotics and biocides. An archetypal RND pump of Escherichia coli, AcrB, is known to exist as a homotrimer, and this construction is essential for drug pumping through the functionally rotating mechanism. MdtBC, however, appears different because two pump genes coexist within a single operon, and genetic deletion… CONTINUE READING

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