Multidrug Efflux Systems in Gram-negative Bacteria

  title={Multidrug Efflux Systems in Gram-negative Bacteria},
  author={Maria Aparecida Scatamburlo Moreira and Edmar Chartone de Souza and C{\'e}lia Alencar de Moraes},
Multidrug efflux mechanisms in bacteria contribute significantly to intrinsic and acquired resistance to antimicrobial agents. Genome analysis have confirmed the broad distribution of these systems in Gramnegative as well as in Gram-positive bacteria. Among resistance mechanisms, the multidrug efflux system or pump deserves special attention, since a cell that has acquired it can simultaneously diminish or even suppress the susceptibility to a wide range of antimicrobials. The efflux system is… CONTINUE READING