Multidrug‐resistant Acinetobacter meningitis in a 3‐year‐old boy treated with i.v. colistin

@article{Lee2008MultidrugresistantAM,
  title={Multidrug‐resistant Acinetobacter meningitis in a 3‐year‐old boy treated with i.v. colistin},
  author={Soo Young Lee and Jae Wook Lee and Dae Chul Jeong and Seung Yeon Chung and Dong Sup Chung and Jin Han Kang},
  journal={Pediatrics International},
  year={2008},
  volume={50}
}
© 2008 Japan Pediatric Society Acinetobacter calcoaceticus – baumannii complex is a non-motile, aerobic, Gram-negative coccobacillus that causes pneumonia, bacteremia, meningitis, urinary tract infection and surgical-site infections. It has become an important opportunistic pathogen due to its persistence in the hospital environment and its multidrugresistant (MDR) patterns, presenting a therapeutic challenge. 1 
Multidrug-resistant Acinetobacter baumannii infection in children
TLDR
The case of a young patient affected by AIDS, who suffered brain toxoplasmosis and sepsis due to multidrug-resistant A baumannii, is reported, and this bacterial infection was successfully treated with colistin and tigecycline.
Postoperative multidrug-resistant Acinetobacter baumannii meningitis successfully treated with intravenous doxycycline and intraventricular gentamicin: A case report
TLDR
Doxycycline and gentamicin were shown to be effective and safe in the treatment of a pediatric case of MDRAB meningitis and cured a 1-year-old girl with a choroid plexus papilloma.
Acinetobacter species meningitis in children: a case series from Karachi, Pakistan.
TLDR
Post-neurosurgical multidrug-resistant and pan-resistant Acinetobacter meningitis can be successfully treated if appropriate antimicrobial therapy is instituted early, and the role of IT polymyxin B administration alone versus combination therapy (IV and IT) needs further study.
Acinetobacter baumannii meningitis in children: a case series and literature review
TLDR
Intrathecal or intraventricular polymyxin administration is expected to be an effective choice for meningitis but requires further study.
Colistin administration to pediatric and neonatal patients
TLDR
Colistin intravenous administration appears well tolerated even at higher than previously recommended doses and of prolonged duration, and only two of the three deaths were infection-related.
Systematic review of invasive Acinetobacter infections in children.
  • Jia Hu, Joan L. Robinson
  • Medicine, Biology
    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
  • 2010
TLDR
The study of the mechanism of colonization and infection of children in intensive care units and of neonates in tropical countries may provide some insight into prevention of invasive infections.
Intravenous Colistin Administration in Neonates
TLDR
Colistimethate intravenous administration appears to be safe and efficacious for multidrug-resistant Gram-negative infections in neonates, including preterm and extremely low birth weight neonates.
Intravenous polymyxins: Revival with puzzle.
TLDR
Evidence from 47 clinical trials or case series showed that polymyxins based regimens are effective and have less toxicity compared with previous trials, though a few doubts remain.
Convergence of Biofilm Formation and Antibiotic Resistance in Acinetobacter baumannii Infection
Acinetobacter baumannii (A. baumannii) is a leading cause of nosocomial infections as this pathogen has certain attributes that facilitate the subversion of natural defenses of the human body. A.
Impact of P-Glycoprotein Inhibition and Lipopolysaccharide Administration on Blood-Brain Barrier Transport of Colistin in Mice
TLDR
It is demonstrated that the BBB transport of colistin is negligible in healthy mice; however, brain concentrations of colistsin can be significantly enhanced during systemic inflammation, as might be observed in infected patients.
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