Multidrug‐resistant Acinetobacter meningitis in a 3‐year‐old boy treated with i.v. colistin

  title={Multidrug‐resistant Acinetobacter meningitis in a 3‐year‐old boy treated with i.v. colistin},
  author={Soo Young Lee and Jae Wook Lee and Dae Chul Jeong and Seung Yeon Chung and Dong Sup Chung and Jin Han Kang},
  journal={Pediatrics International},
© 2008 Japan Pediatric Society Acinetobacter calcoaceticus – baumannii complex is a non-motile, aerobic, Gram-negative coccobacillus that causes pneumonia, bacteremia, meningitis, urinary tract infection and surgical-site infections. It has become an important opportunistic pathogen due to its persistence in the hospital environment and its multidrugresistant (MDR) patterns, presenting a therapeutic challenge. 1 
Multidrug-resistant Acinetobacter baumannii infection in children
The case of a young patient affected by AIDS, who suffered brain toxoplasmosis and sepsis due to multidrug-resistant A baumannii, is reported, and this bacterial infection was successfully treated with colistin and tigecycline.
Postoperative multidrug-resistant Acinetobacter baumannii meningitis successfully treated with intravenous doxycycline and intraventricular gentamicin: A case report
Doxycycline and gentamicin were shown to be effective and safe in the treatment of a pediatric case of MDRAB meningitis and cured a 1-year-old girl with a choroid plexus papilloma.
Acinetobacter species meningitis in children: a case series from Karachi, Pakistan.
Post-neurosurgical multidrug-resistant and pan-resistant Acinetobacter meningitis can be successfully treated if appropriate antimicrobial therapy is instituted early, and the role of IT polymyxin B administration alone versus combination therapy (IV and IT) needs further study.
Acinetobacter baumannii meningitis in children: a case series and literature review
Intrathecal or intraventricular polymyxin administration is expected to be an effective choice for meningitis but requires further study.
Colistin administration to pediatric and neonatal patients
Colistin intravenous administration appears well tolerated even at higher than previously recommended doses and of prolonged duration, and only two of the three deaths were infection-related.
Systematic review of invasive Acinetobacter infections in children.
  • Jia Hu, Joan L. Robinson
  • Medicine, Biology
    The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
  • 2010
The study of the mechanism of colonization and infection of children in intensive care units and of neonates in tropical countries may provide some insight into prevention of invasive infections.
Intravenous Colistin Administration in Neonates
Colistimethate intravenous administration appears to be safe and efficacious for multidrug-resistant Gram-negative infections in neonates, including preterm and extremely low birth weight neonates.
Intravenous polymyxins: Revival with puzzle.
Evidence from 47 clinical trials or case series showed that polymyxins based regimens are effective and have less toxicity compared with previous trials, though a few doubts remain.
Convergence of Biofilm Formation and Antibiotic Resistance in Acinetobacter baumannii Infection
Acinetobacter baumannii (A. baumannii) is a leading cause of nosocomial infections as this pathogen has certain attributes that facilitate the subversion of natural defenses of the human body. A.
Impact of P-Glycoprotein Inhibition and Lipopolysaccharide Administration on Blood-Brain Barrier Transport of Colistin in Mice
It is demonstrated that the BBB transport of colistin is negligible in healthy mice; however, brain concentrations of colistsin can be significantly enhanced during systemic inflammation, as might be observed in infected patients.


Successful Treatment of Multidrug-Resistant Acinetobacter baumannii Central Nervous System Infections with Colistin
Acinetobacter baumannii may cause severe central nervous system (CNS) infections, such as meningitis and ventriculitis, especially in patients undergoing neurosurgical procedures or head trauma.
Treatment of multidrug resistant Acinetobacter
This review summarizes the most recent literature pertaining to the clinical management of infections with this bacteria emphasizing in-vitro antimicrobial resistance patterns and antimicrobial efficacy in animals and humans.
Successful treatment of Acinetobacter meningitis with meropenem and rifampicin.
This isolate was the first and unique P. aeruginosa harbouring this resistance phenotype in the authors' hospital and could therefore constitute the first report of the dissemination of VIM-MBL in the Middle East.
Successful Treatment of Multidrug-Resistant Acinetobacter baumannii Meningitis with Intravenous Colistin Sulfomethate Sodium
A clinical case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to polymyxins and treated successfully with intravenous colistin sulfomethate sodium is described.
Underlying characteristics of patients harboring highly resistant Acinetobacter baumannii.
Antibiotics, Foley catheters, and tracheostomy/ventilator usage were strongly associated with AB isolation, indicating colonization is a marker of severe illness but is not necessarily causal.
Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment.
  • J. Cisneros, J. Rodríguez-Baño
  • Biology, Medicine
    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
  • 2002
A. baumannii is a bacterium that appears to have a propensity for developing multiple antimicrobial resistance extremely rapidly, and these data are disturbing because the therapeutic possibilities decrease while inappropriate antimicrobial treatment contributes to patient mortality.
Mortality and the increase in length of stay attributable to the acquisition of Acinetobacter in critically ill patients.
AB acquisition involved an excess LOS in ICU patients and increased risk of death, but the latter could be found only in patients with proven infection.