Multidisciplinary clinical management of paroxysmal nocturnal hemoglobinuria.

  title={Multidisciplinary clinical management of paroxysmal nocturnal hemoglobinuria.},
  author={Fahri Şahin and Melda Comert Ozkan and Nihal Gokmen Mete and Mumtaz Yilmaz and Nevin Oruç and Alev Gurgun and Meral Kayikçioğlu and Ayse Guler and Figen Gokcay and Ferda Bilgir and Cengiz Ceylan and Oktay Bilgir and Ismail Sari and Guray Saydam},
  journal={American journal of blood research},
  volume={5 1},
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired disease caused by clonal expansion of one or more hematopoietic stem cell (HSC) lines due to a somatic mutation of the phosphatidylinositol glycan anchor (PIG-A) gene located on Xp22.1. PNH incidence is 1.5-2 cases per million of the population per year. PNH can affect multiple systems in the body and requires multidisciplinary clinical management. Patients can manifest with severe pancytopenia, life-threatening thrombosis affecting… CONTINUE READING


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