Multidimensional signatures in antimicrobial peptides.

  title={Multidimensional signatures in antimicrobial peptides.},
  author={Nannette Y Yount and Michael R Yeaman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 19},
Conventional analyses distinguish between antimicrobial peptides by differences in amino acid sequence. Yet structural paradigms common to broader classes of these molecules have not been established. The current analyses examined the potential conservation of structural themes in antimicrobial peptides from evolutionarily diverse organisms. Using proteomics, an antimicrobial peptide signature was discovered to integrate stereospecific sequence patterns and a hallmark three-dimensional motif… CONTINUE READING

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