Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.

@article{Wu2009MultidentateSI,
  title={Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells.},
  author={Shuangding Wu and Sofie Vossius and Souad Rahmouni and Ana V Miletic and Torkel Vang and Jesus Vazquez-Rodriguez and Fabio Cerignoli and Yutaka Arimura and Scott Williams and Tikva Hayes and Michel P. Moutschen and Stefan Vasile and Maurizio Pellecchia and Tomas M. Mustelin and Lutz Tautz},
  journal={Journal of medicinal chemistry},
  year={2009},
  volume={52 21},
  pages={6716-23}
}
Loss of VHR phosphatase causes cell cycle arrest in HeLa carcinoma cells, suggesting that VHR inhibition may be a useful approach to halt the growth of cancer cells. We recently reported that VHR is upregulated in several cervix cancer cell lines as well as in carcinomas of the uterine cervix. Here we report the development of multidentate small-molecule inhibitors of VHR that inhibit its enzymatic activity at nanomolar concentrations and exhibit antiproliferative effects on cervix cancer cells… CONTINUE READING
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