Multicriteria Gene Screening for Analysis of Differential Expression with DNA Microarrays

  title={Multicriteria Gene Screening for Analysis of Differential Expression with DNA Microarrays},
  author={Alfred O. Hero and Gilles Fleury and Alan J. Mears and Anand Swaroop},
  journal={EURASIP J. Adv. Sig. Proc.},
This paper introduces a statistical methodology for identification of differentially expressed genes in DNA microarray experiments based on multiple criteria. These criteria are: false discovery rate (FDR); variance-normalized differential expression levels (paired t statistics); and minimum acceptable difference (MAD). The methodology also provides a set of simultaneous FDR confidence intervals on the true expression differences. The analysis can be implemented as a two stage algorithm in… CONTINUE READING


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