Multicopy suppressors of phenotypes resulting from the absence of yeast VDAC encode a VDAC-like protein.

@article{BlachlyDyson1997MulticopySO,
  title={Multicopy suppressors of phenotypes resulting from the absence of yeast VDAC encode a VDAC-like protein.},
  author={Elizabeth Blachly-Dyson and Jing Song and William J. Wolfgang and Marco Colombini and Michael Forte},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 10},
  pages={5727-38}
}
The permeability of the outer mitochondrial membrane to most metabolites is believed to be based in an outer membrane, channel-forming protein known as VDAC (voltage-dependent anion channel). Although multiple isoforms of VDAC have been identified in multicellular organisms, the yeast Saccharomyces cerevisiae has been thought to contain a single VDAC gene, designated POR1. However, cells missing the POR1 gene (delta por1) were able to grow on yeast media containing a nonfermentable carbon… CONTINUE READING
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