Multicopy suppression underpins metabolic evolvability.

@article{Patrick2007MulticopySU,
  title={Multicopy suppression underpins metabolic evolvability.},
  author={Wayne M. Patrick and Erik M Quandt and Dan B. Swartzlander and Ichiro Matsumura},
  journal={Molecular biology and evolution},
  year={2007},
  volume={24 12},
  pages={2716-22}
}
Our understanding of the origins of new metabolic functions is based upon anecdotal genetic and biochemical evidence. Some auxotrophies can be suppressed by overexpressing substrate-ambiguous enzymes (i.e., those that catalyze the same chemical transformation on different substrates). Other enzymes exhibit weak but detectable catalytic promiscuity in vitro (i.e., they catalyze different transformations on similar substrates). Cells adapt to novel environments through the evolution of these… CONTINUE READING
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