Multicomponent pharmaceutical cocrystals: furosemide and pentoxifylline.

Abstract

The combination of the active pharmaceutical ingredients furosemide [4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid] and pentoxifylline [3,7-dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione] produces a 1:1 cocrystal, C(12)H(11)ClN(2)O(5)S·C(13)H(18)N(4)O(3), (I), a 1:1 cocrystal hydrate, C(12)H(11)ClN(2)O(5)S·C(13)H(18)N(4)O(3)·H(2)O, (II… (More)
DOI: 10.1107/S0108270112045866

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