Multicomponent mannose-containing liposomes efficiently deliver RNA in murine immature dendritic cells and provide productive anti-tumour response in murine melanoma model.

@article{Markov2015MulticomponentML,
  title={Multicomponent mannose-containing liposomes efficiently deliver RNA in murine immature dendritic cells and provide productive anti-tumour response in murine melanoma model.},
  author={Oleg V. Markov and Nadezhda L. Mironova and Elena V. Shmendel and Roman N Serikov and Nina G. Morozova and Mikhail A Maslov and Valentin V. Vlassov and Marina A. Zenkova},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={213},
  pages={45-56}
}
Here we demonstrate the ability of mannosylated liposomes (ML) targeted to mannose receptors (MR) to perform the targeted delivery of model plasmid DNA encoding EGFP and total tumour RNA into murine bone-marrow-derived dendritic cells (DCs) and enhance the efficiency of anti-tumour response triggered by these DCs in murine melanoma model. ML consist of cationic lipid 2X3 (1,26-Bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride), helper lipid DOPE (1,2… CONTINUE READING
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