Multicomponent anthrax toxin display and delivery using bacteriophage T4.

@article{Shivachandra2007MulticomponentAT,
  title={Multicomponent anthrax toxin display and delivery using bacteriophage T4.},
  author={S. B. Shivachandra and Qin Li and K. Peachman and G. Matyas and S. Leppla and C. Alving and M. Rao and V. Rao},
  journal={Vaccine},
  year={2007},
  volume={25 7},
  pages={
          1225-35
        }
}
We describe a multicomponent antigen display and delivery system using bacteriophage T4. Two dispensable outer capsid proteins, Hoc (highly antigenic outer capsid protein, 155 copies) and Soc (small outer capsid protein, 810 copies), decorate phage T4 capsid. These proteins bind to the symmetrically localized capsid sites, which appear following prohead assembly and expansion. We hypothesized that multiple antigens fused to Hoc can be displayed on the same capsid and such particles can elicit… Expand
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