Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma.

@article{Rao1998MulticolorSK,
  title={Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma.},
  author={Pulivarthi H. Rao and Juan C. Cigudosa and Yi Ning and Mar{\'i}a Jos{\'e} Calasanz and Shinsuke Iida and Shinichi Tagawa and Joseph Michaeli and Bernard Klein and Riccardo Dalla-Favera and Suresh C. Jhanwar and Thomas Ried and Raju S. K. Chaganti},
  journal={Blood},
  year={1998},
  volume={92 5},
  pages={1743-8}
}
Karyotypic information on multiple myeloma (MM) is less extensive than that on other myeloid or lymphoid malignancies due to low mitotic activity of plasma cells. An add(14)(q32) marker chromosome has been reported to be the most frequent recurring abnormality in clonally abnormal cases; in approximately one third of the latter cases, this marker has been identified as a der(14)t(11;14)(q13;q32) chromosome. To map chromosomal breakpoints, characterize the add(14)(q32) marker chromosomes, and to… CONTINUE READING