Multicolor Spectral Karyotyping of Human Chromosomes

@article{Schrck1996MulticolorSK,
  title={Multicolor Spectral Karyotyping of Human Chromosomes},
  author={Evelin Schr{\"o}ck and Stanislas du Manoir and Tim Veldman and Brigitte Schoell and Johannes Wienberg and Malcolm A. Ferguson-Smith and Yi Ning and David H. Ledbetter and I. Bar-Am and Dirk G. Soenksen and Yuval Garini and Thomas Ried},
  journal={Science},
  year={1996},
  volume={273},
  pages={494 - 497}
}
The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were… Expand
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