Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing.

@article{Casasent2018MulticlonalII,
  title={Multiclonal Invasion in Breast Tumors Identified by Topographic Single Cell Sequencing.},
  author={Anna K Casasent and Aislyn Schalck and Ruli Gao and Emi Sei and Annalyssa Long and William Pangburn and Tod D Casasent and Funda Meric-Bernstam and Mary E. Edgerton and Nicholas Navin},
  journal={Cell},
  year={2018},
  volume={172 1-2},
  pages={205-217.e12}
}
Ductal carcinoma in situ (DCIS) is an early-stage breast cancer that infrequently progresses to invasive ductal carcinoma (IDC). Genomic evolution has been difficult to delineate during invasion due to intratumor heterogeneity and the low number of tumor cells in the ducts. To overcome these challenges, we developed Topographic Single Cell Sequencing (TSCS) to measure genomic copy number profiles of single tumor cells while preserving their spatial context in tissue sections. We applied TSCS to… CONTINUE READING

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