Multiclass cancer diagnosis using tumor gene expression signatures.

  title={Multiclass cancer diagnosis using tumor gene expression signatures.},
  author={Sridhar Ramaswamy and Pablo Tamayo and Robert Rifkin and Sayan Mukherjee and C H Yeang and Michael Angelo and Christine M Ladd and Michael P Reich and Eva Latulippe and Jill P. Mesirov and Tomaso A. Poggio and William Gerald and Massimo F. Loda and Eric S. Lander and Todd R. Golub},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={98 26},
The optimal treatment of patients with cancer depends on establishing accurate diagnoses by using a complex combination of clinical and histopathological data. In some instances, this task is difficult or impossible because of atypical clinical presentation or histopathology. To determine whether the diagnosis of multiple common adult malignancies could be achieved purely by molecular classification, we subjected 218 tumor samples, spanning 14 common tumor types, and 90 normal tissue samples to… CONTINUE READING
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