Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease.

@article{Azzouz2002MulticistronicLV,
  title={Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease.},
  author={Mimoun Azzouz and Enca Martin-Rendon and Robert D. Barber and Kyriacos A. Mitrophanous and Emma E. Carter and Jonathan B Rohll and Susan Mary Kingsman and Alan John Kingsman and Nicholas D Mazarakis},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 23},
  pages={
          10302-12
        }
}
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra. This loss leads to complete dopamine depletion in the striatum and severe motor impairment. It has been demonstrated previously that a lentiviral vector system based on equine infectious anemia virus (EIAV) gives rise to highly efficient and sustained transduction of neurons in the rat brain. Therefore, a dopamine replacement strategy using EIAV has been… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 96 CITATIONS

Gene therapy in Parkinson’s disease

  • Cell and Tissue Research
  • 2004
VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

12 Gene Therapy for Parkinson ’ s Disease

VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Gene Therapy for Parkinson's Disease

  • Parkinson's disease
  • 2012
VIEW 4 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Gene Therapy for Parkinson's Disease.

  • Progress in neurological surgery
  • 2018
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Translational research for Parkinson׳s disease: The value of pre-clinical primate models.

  • European journal of pharmacology
  • 2015
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2003
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

  • Averaged 7 Citations per year over the last 3 years

  • 20% Increase in citations per year in 2018 over 2017

References

Publications referenced by this paper.
SHOWING 1-10 OF 56 REFERENCES

Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2002
VIEW 10 EXCERPTS
HIGHLY INFLUENTIAL

New methods to titrate EIAV-based lentiviral vectors.

  • Molecular therapy : the journal of the American Society of Gene Therapy
  • 2002
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The design, production, safety, evaluation

ND, SM Kingsman
  • 2002

Similar Papers

Loading similar papers…