Multicentric sporadic gastrointestinal stromal tumors (GISTs) of the stomach with distinct clonal origin: differential diagnosis to familial and syndromal GIST variants and peritoneal metastasis.

@article{Haller2007MulticentricSG,
  title={Multicentric sporadic gastrointestinal stromal tumors (GISTs) of the stomach with distinct clonal origin: differential diagnosis to familial and syndromal GIST variants and peritoneal metastasis.},
  author={Florian Haller and Hans-Juergen Schulten and Thomas Armbrust and Claus Langer and Bastian Gunawan and L{\'a}szl{\'o} F{\"u}zesi},
  journal={The American journal of surgical pathology},
  year={2007},
  volume={31 6},
  pages={933-7}
}
Most sporadic gastrointestinal stromal tumors (GISTs) occur solitary, whereas a multicentric appearance is suspicious for a familial or syndromal setting such as with germline mutations of proto-oncogene tyrosine protein kinase Kit (KIT) or platelet derived growth factor receptor alpha (PDGFRA), or even for metastases. The aim of this study was to evaluate whether multicentric sporadic GISTs are of clonal origin. Four patients with 1 clinically apparent tumor (mean size 5.6 cm) and 1 to 3… CONTINUE READING

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