Multicentre randomized placebo-controlled trial of ursodeoxycholic acid with or without colchicine in symptomatic primary biliary cirrhosis.

@article{Almasio2000MulticentreRP,
  title={Multicentre randomized placebo-controlled trial of ursodeoxycholic acid with or without colchicine in symptomatic primary biliary cirrhosis.},
  author={Piero Luigi Almasio and Annarosa Floreani and Maria Chiaramonte and Giuseppe Provenzano and P Battezzati and Andrea Crosignani and Mauro Podda and Luca Todros and Floriano Rosina and Gioconda Saccoccio and Federico Manenti and Giorgio Ballardini and Fabrizio Bianchi and Peter J. Scheuer and Susan E. Davies and Antonio Crax{\`i}},
  journal={Alimentary pharmacology & therapeutics},
  year={2000},
  volume={14 12},
  pages={
          1645-52
        }
}
AIM To establish the efficacy of combination therapy with ursodeoxycholic acid (UDCA) and colchicine in patients with symptomatic primary biliary cirrhosis (PBC), defined by the presence of liver cirrhosis, pruritus or bilirubin exceeding 2 mg/mL. METHODS A total of 90 patients were randomly assigned to ursodeoxycholic acid 500 mg/daily plus placebo (UDCA group, n=44), or ursodeoxycholic acid at the same dosage plus colchicine, 1 mg/daily (UDCA/C group, n=46). The two groups were comparable… CONTINUE READING
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