Multicentre randomised phase II trial of gemcitabine+platinum, with or without trastuzumab, in advanced or metastatic urothelial carcinoma overexpressing Her2.

@article{Oudard2015MulticentreRP,
  title={Multicentre randomised phase II trial of gemcitabine+platinum, with or without trastuzumab, in advanced or metastatic urothelial carcinoma overexpressing Her2.},
  author={Stephane Oudard and St{\'e}phane Culine and Yann Alexandre Vano and François Goldwasser and Christine A Theodore and Thierry Nguyen and Eric Voog and E. Anandha Banu and Annick Vieillefond and Franck Priou and Ga{\"e}l Deplanque and Gw{\'e}naelle Gravis and Alain Mure Ravaud and Jean Michel Vannetzel and Jean-Pascal Machiels and Xavier Muracciole and M. F. Pichon and J O Bay and R{\'e}za Elaidi and Corine Teghom and François Radvanyi and Philippe Beuzeboc},
  journal={European journal of cancer},
  year={2015},
  volume={51 1},
  pages={45-54}
}
AIM To investigate the efficacy and safety of gemcitabine and platinum salt, with or without trastuzumab, in patients with locally advanced or metastatic urothelial carcinoma overexpressing Her2. METHODS The main eligibility criterion was Her2 overexpression on immunohistochemistry (IHC 2+ or 3+) of primary tumour tissue confirmed by fluorescence in situ hybridisation (FISH). Patients were randomised to Arm A: gemcitabine 1000mg/m(2) (days 1 and 8) plus either cisplatin (70mg/m(2)) or… CONTINUE READING

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