Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis.

@article{Sokol1993MulticenterTO,
  title={Multicenter trial of d-alpha-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis.},
  author={Ronald J. Sokol and Nancy A Butler-Simon and Clay Conner and James E. Heubi and Frank R Sinatra and Frederick J. Suchy and Melvin B. Heyman and Jean Perrault and Robert J. Rothbaum and Joseph Levy},
  journal={Gastroenterology},
  year={1993},
  volume={104 6},
  pages={1727-35}
}
BACKGROUND Malabsorption and deficiency of vitamin E causing neurological degeneration are common consequences of chronic childhood cholestatic liver disease. The objective of this study was to determine the long-term efficacy and safety of d-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in correcting vitamin E deficiency in children with chronic cholestasis who were unresponsive to other forms of oral vitamin E. METHODS Sixty vitamin E-deficient children with chronic cholestasis… CONTINUE READING
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