Multicenter trial of L-carnitine in maintenance hemodialysis patients. I. Carnitine concentrations and lipid effects.
@article{Golper1990MulticenterTO, title={Multicenter trial of L-carnitine in maintenance hemodialysis patients. I. Carnitine concentrations and lipid effects.}, author={Thomas A Golper and Marsha Wolfson and S. Ahmad and Raimund Hirschberg and Paul S. Kurtin and L A Katz and R W Nicora and Donald Ashbrook and Joel D. Kopple}, journal={Kidney international}, year={1990}, volume={38 5}, pages={ 904-11 } }
Previous studies have reported conflicting results of carnitine supplementation on plasma lipids in patients with chronic renal failure. We therefore performed a four center, double-blind placebo controlled trial to evaluate the effects of post-hemodialysis intravenous injection of L-carnitine in ESRD patients on maintenance hemodialysis. Thirty-eight patients received up to six months of L-carnitine infusions (20 mg/kg) post-dialysis and 44 patients received placebo infusions. In both groups…
111 Citations
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L-carnitine cannot be recommended for treating the dyslipidemia of maintenance hemodialysis patients and a promising effect of L-c Carnitine on anemia management is suggested.
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L-C Carnitine increased the blood acylcarnitine levels, enhanced fatty acid metabolism, and affected AAs metabolism; this may be beneficial for energy production within the cardiac and skeletal muscles.
Pharmacokinetic considerations for the therapeutic use of carnitine in hemodialysis patients.
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Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients.
- MedicineAmerican journal of kidney diseases : the official journal of the National Kidney Foundation
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Effects of carnitine and coenzyme Q10 on lipid profile and serum levels of lipoprotein(a) in maintenance hemodialysis patients on statin therapy.
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It is shown that supplementation with carnitine and coenzyme Q10 could reduce serum levels of lipoprotein(a) in maintenance hemodialysis patients treated with statins.
Effect of carnitine supplementation on cardiac function in hemodialyzed children
- Medicine, BiologyActa paediatrica Japonica : Overseas edition
- 1998
3 months of L‐carnitine supplementation resulted in a significant increase in blood carnitine levels and the FC/AC ratio, but this was not associated with any significant improvement of cardiac function and no significant changes were observed in plasma triglycerides, total cholesterol or other lipoprotein parameters before or after carnitines supplementation.
Total carnitine and acylated carnitine ratio: relationship of free carnitine with lipid parameters in pediatric dialysis patients.
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Elevated triglycerides were associated with elevated AC, suggesting carnitine insufficiency in pediatric patients on chronic PD or HD, and nutritional status, biochemical parameters, and fasting plasma lipoprotein concentrations were evaluated.
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It is suggested that L-carnitine can be effective in the management of hypertriglyceridemia in the hemodialyzed patient especially when low high-density lipoprotein-cholesterol levels are present.