Multicenter trial of L-Deprenylin Parkinson disease

@article{Ruggieri2005MulticenterTO,
  title={Multicenter trial of L-Deprenylin Parkinson disease},
  author={Stefano Ruggieri and Alessandro Denaro and Giuseppe Meco and Angelico Carta and Fabrizio Stocchi and Alessandro Agnoli},
  journal={The Italian Journal of Neurological Sciences},
  year={2005},
  volume={7},
  pages={133-137}
}
A multicenter trial was conducted at 9 Neurology Departements to evaluate the action of L-Deprenyl, a specific monoamine oxidase-B inhibitor, combined with L-Dopa in the treatment of Parkinson disease. In all, 76 patients were treated, 33 women and 43 men, on stable treatment with L-Dopa+aromatic decarboxylase inhibitors (DI) for at least 6 months. After a 50% reduction of the L-Dopa dose, all received L-Deprenyl 5 mg twice daily for 35 day. The combined treatment resulted in a definite… 
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