Multicenter study of voriconazole pharmacokinetics and therapeutic drug monitoring.

@article{Dolton2012MulticenterSO,
  title={Multicenter study of voriconazole pharmacokinetics and therapeutic drug monitoring.},
  author={Michael J. Dolton and John Ernest Ray and Sharon C-A Chen and Kingsley Ng and Lisa G. Pont and Andrew J. McLachlan},
  journal={Antimicrobial agents and chemotherapy},
  year={2012},
  volume={56 9},
  pages={
          4793-9
        }
}
Voriconazole is a first-line agent in the treatment of many invasive fungal infections and is known to display highly variable pharmacokinetics. Previous studies of voriconazole therapeutic drug monitoring (TDM) have suggested concentration monitoring to be clinically useful but have been limited by small patient samples at a single institution. This multicenter retrospective study aimed to investigate relationships between voriconazole concentration and clinical outcomes and adverse events and… CONTINUE READING
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