Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting

@article{OstroskyZeichner2007MulticenterRD,
  title={Multicenter retrospective development and validation of a clinical prediction rule for nosocomial invasive candidiasis in the intensive care setting},
  author={Luis Ostrosky-Zeichner and C. Sable and Jan Sobel and B. D. Alexander and G. Donowitz and Vincent Kan and C. A. Kauffman and D. Kett and R. Larsen and V. Morrison and Marcio Nucci and P. G. Pappas and M. E. Bradley and S. Major and Luan Zimmer and Dennis D. Wallace and W. E. Dismukes and J. H. Rex},
  journal={European Journal of Clinical Microbiology & Infectious Diseases},
  year={2007},
  volume={26},
  pages={271-276}
}
The study presented here was performed in order to create a rule that identifies subjects at high risk for invasive candidiasis in the intensive care setting. Retrospective review and statistical modelling were carried out on 2,890 patients who stayed at least 4 days in nine hospitals in the USA and Brazil; the overall incidence of invasive candidiasis in this group was 3% (88 cases). The best performing rule was as follows: Any systemic antibiotic (days 1–3) OR presence of a central venous… CONTINUE READING

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