Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group.

@article{Mayer1997MulticenterRT,
  title={Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study Group.},
  author={Alan D. Mayer and Jan Dmitrewski and Jean Paul Squifflet and Tatiana Besse and Bernd Grabensee and Barbara L. Klein and Friedrich Wilhelm Eigler and Uwe W Heemann and Rudolf Pichlmayr and Matthias Behrend and Yves F Ch Vanrenterghem and J. C. J. van der Donck and Johannes P. van Hooff and Maarten Christiaans and Jos{\'e} Mar{\'i}a Morales and A. Torregrosa Andr{\'e}s and Robert Wood Johnson and Colin Short and Bryan Buchholz and N Rehmert and Walter Land and S. Schleibner and John L R Forsythe and David Talbot and Erich Pohanka},
  journal={Transplantation},
  year={1997},
  volume={64 3},
  pages={436-43}
}
BACKGROUND To confirm the results of a number of studies conducted in Europe, the United States, and Japan, this multicenter, randomized trial compared the 12-month efficacy and safety of tacrolimus- and cyclosporine-based immunosuppressive regimens in the prevention of renal allograft rejection. METHODS A total of 448 renal transplant recipients were recruited from 15 centers and assigned to receive triple-drug therapy consisting of tacrolimus (n=303) or cyclosporine (n=145) in conjunction… CONTINUE READING

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