Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpoints.

@article{Davis2010MulticenterEO,
  title={Multicenter evaluation of infant lung function tests as cystic fibrosis clinical trial endpoints.},
  author={Stephanie D Davis and Margaret Rosenfeld and Gwendolyn S Kerby and Lyndia C. Brumback and Margaret H Kloster and James D. Acton and Andrew A. Colin and Carol K. Conrad and Meeghan A Hart and Peter W Hiatt and Peter J. Mogayzel and Robin C Johnson and Stephanie L Wilcox and Robert G. Castile},
  journal={American journal of respiratory and critical care medicine},
  year={2010},
  volume={182 11},
  pages={1387-97}
}
RATIONALE The conducting of clinical trials in infants with cystic fibrosis (CF) has been hindered by lack of sensitive outcome measures. OBJECTIVES To evaluate safety, feasibility, and ability to detect abnormalities in lung function of serial pulmonary function tests (PFTs) in infants with CF. METHODS Multicenter observational study using a commercial device, rigorous training, ongoing quality control, and over-reading of data by an independent panel. Raised volume rapid thoracoabdominal… CONTINUE READING
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