Multicenter evaluation of a new automated fourth-generation human immunodeficiency virus screening assay with a sensitive antigen detection module and high specificity.

@article{Weber2002MulticenterEO,
  title={Multicenter evaluation of a new automated fourth-generation human immunodeficiency virus screening assay with a sensitive antigen detection module and high specificity.},
  author={Bernard H F Weber and Lutz Guertler and Rigmor Thorstensson and Ulrike Michl and Annelies M{\"u}hlbacher and Philippe Buergisser and Roberto G Villaescusa and Adolfo Eiras and Christian H Gabriel and Herbert Stekel and Srivilai Tanprasert and Sinenaart Oota and M J Silvestre and Cristina B Marques and Maria Cec{\'i}lia Teixeira Ladeira and H. Kropp-v. Rabenau and Annemarie Berger and Urban Schmitt and Walter Melchior},
  journal={Journal of clinical microbiology},
  year={2002},
  volume={40 6},
  pages={1938-46}
}
Fourth-generation assays for the simultaneous detection of human immunodeficiency virus (HIV) antigen and antibody that were available on the international market until now have antigen detection modules with relatively poor sensitivity and produce a higher rate of false-positive results than third-generation enzyme immunoassays (EIAs). The new Cobas Core HIV Combi EIA with an improved sensitivity for HIV p24 antigen was compared to alternative fourth- and third-generation assays, the p24… CONTINUE READING