Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study.

@article{Harris2016MulticenterFS,
  title={Multicenter Feasibility Study of Tumor Molecular Profiling to Inform Therapeutic Decisions in Advanced Pediatric Solid Tumors: The Individualized Cancer Therapy (iCat) Study.},
  author={Marian Harris and Steven G DuBois and Julia L Glade Bender and AeRang Kim and Brian D Crompton and Erin Parker and Ian P Dumont and Andrew L Hong and Dongjing Guo and Alanna J Church and Kimberly Stegmaier and Charles W. M. Roberts and Suzanne Shusterman and Wendy B London and Laura E Macconaill and Neal I. Lindeman and Lisa Diller and Carlos Rodriguez-Galindo and Katherine A Janeway},
  journal={JAMA oncology},
  year={2016},
  volume={2 5},
  pages={
          608-615
        }
}
Importance Pediatric cancers represent a unique case with respect to cancer genomics and precision medicine, as the mutation frequency is low, and targeted therapies are less available. Consequently, it is unknown whether clinical sequencing can be of benefit. Objective To assess the feasibility of identifying actionable alterations and making individualized cancer therapy (iCat) recommendations in pediatric patients with extracranial solid tumors. Design, Setting, and Participants Clinical… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 46 CITATIONS

Barriers preventing the adoption of comprehensive cancer genomic profiling in the clinic.

  • Expert review of molecular diagnostics
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 17 REFERENCES

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2014
VIEW 3 EXCERPTS