Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder.

@article{Coric2010MulticenterRD,
  title={Multicenter, randomized, double-blind, active comparator and placebo-controlled trial of a corticotropin-releasing factor receptor-1 antagonist in generalized anxiety disorder.},
  author={Vladimir Coric and Howard H. Feldman and Dan A. Oren and Anantha S Shekhar and Joseph A. Pultz and Randy C. Dockens and Xiaoling Wu and Kimberly A Gentile and Shu-Pang Huang and Eileen Sproat Emison and Terrye Delmonte and Bernadette B D'Souza and Daniel L Zimbroff and Jack A Grebb and Andrew W. Goddard and Elyse G Stock},
  journal={Depression and anxiety},
  year={2010},
  volume={27 5},
  pages={
          417-25
        }
}
BACKGROUND Antagonism of corticotropin-releasing factor (CRF) receptors has been hypothesized as a potential target for the development of novel anxiolytics. This study was designed to determine the safety and efficacy of pexacerfont, a selective CRF-1 receptor antagonist, in the treatment of generalized anxiety disorder (GAD). METHOD This was a multicenter, randomized, double-blind, placebo-controlled and active comparator trial. Two hundred and sixty patients were randomly assigned to… CONTINUE READING
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