Multicenter, placebo-controlled study of fluoxetine in seasonal affective disorder.

  title={Multicenter, placebo-controlled study of fluoxetine in seasonal affective disorder.},
  author={Raymond W Lam and Chris P Gorman and M Michalon and Martin Steiner and Anthony J. Levitt and Maria R Corral and G D Watson and Rachel L. Morehouse and Wilson Tam and Russell T. Joffe},
  journal={The American journal of psychiatry},
  volume={152 12},
OBJECTIVE The authors investigated the efficacy and safety of fluoxetine in the treatment of winter seasonal affective disorder. METHOD Sixty-eight outpatients who met the DSM-III-R criteria for recurrent major depressive episodes, seasonal (winter) pattern, were randomly assigned to 5 weeks of treatment with fluoxetine, 20 mg/day (N = 36), or placebo (N = 32). The outcome measures included the 29-item modified Hamilton Depression Rating Scale, administered by experienced clinicians, and the… CONTINUE READING

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