Multicenter, Randomized, Investigator-Masked Study Comparing Brimonidine Tartrate 0.1% and Timolol Maleate 0.5% as Adjunctive Therapies to Prostaglandin Analogues in Normal-Tension Glaucoma

@article{Mizoue2017MulticenterRI,
  title={Multicenter, Randomized, Investigator-Masked Study Comparing Brimonidine Tartrate 0.1\% and Timolol Maleate 0.5\% as Adjunctive Therapies to Prostaglandin Analogues in Normal-Tension Glaucoma},
  author={Shiro Mizoue and Koji Nitta and Motohiro Shirakashi and Akiyoshi Nitta and Shigeki Yamabayashi and Tairo Kimura and Toshihiko Ueda and Ryuji Takeda and Shun Matsumoto and Keiji Yoshikawa},
  journal={Advances in Therapy},
  year={2017},
  volume={34},
  pages={1438-1448}
}
IntroductionThis study compared the efficacy and safety of adjunctive brimonidine tartrate 0.1% ophthalmic solution (brimonidine) and timolol maleate 0.5% ophthalmic solution (timolol) in prostaglandin analogue (PGA)-treated normal-tension glaucoma (NTG), assessing the non-inferiority of brimonidine in terms of intraocular pressure (IOP) reduction.MethodsIn this multicenter, randomized, investigator-masked, parallel-group, clinical study, adjunctive brimonidine or timolol was administered twice… Expand
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