Multicellular spheroids. A review on cellular aggregates in cancer research.

  title={Multicellular spheroids. A review on cellular aggregates in cancer research.},
  author={Wolfgang F Mueller-Klieser},
  journal={Journal of cancer research and clinical oncology},
  volume={113 2},
Cellular aggregates have been used in developmental biology and in experimental cancer research for several decades. Spherical aggregates of malignant cells, i.e. multicellular tumor spheroids, may serve as in vitro models of tumor microregions and of an early, avascular stage of tumor growth. The similarities between the original tumor and the respective spheroids include volume growth kinetics, cellular heterogeneity, e.g. the induction of proliferation gradients and quiescence, as well as… CONTINUE READING

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