Multicellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene

@article{Reddy1979MulticellularOO,
  title={Multicellular origin of fibrosarcomas in mice induced by the chemical carcinogen 3-methylcholanthrene},
  author={A. Lakshma Reddy and Philip J. Fialkow},
  journal={The Journal of Experimental Medicine},
  year={1979},
  volume={150},
  pages={878 - 887}
}
The cellular origin of tumors induced by the chemical carcinogen 3-methylcholanthrene (MCA) was studied in mice with X-chromosome inactivation mosaicism. Because only one of the two X-chromosomes is active in XX somatic cells, a female heterozygous at the X-linked phosphoglycerate kinase (PGK-1) locus for the usual Pgk-1b gene and the variant Pgk-1a has two populations of cells, in the cells of one population, Pgk-1b is active and B-type enzyme is synthesized, whereas in cells of the other… CONTINUE READING
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