Multicell spheroid response to drugs predicted with the comet assay.

  title={Multicell spheroid response to drugs predicted with the comet assay.},
  author={Peggy L. Olive and Judit P. Ban{\'a}th},
  journal={Cancer research},
  volume={57 24},
Multicell spheroids were exposed to DNA-damaging agents with the aim of determining whether prompt DNA damage could be predictive for cell killing and drug resistance. Chinese hamster V79 cells, SiHa human cervical carcinoma cells, and WiDr human colon carcinoma cells were grown as spheroids and exposed to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 4-nitroquinoline-1-oxide (4NQO), doxorubicin, etoposide, actinomycin D, 1-(2-nitro-1-imidazolyl)-3-aziridino-2-propanol (RSU 1069), 3-amino-1,2,4… CONTINUE READING


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