Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

  title={Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes},
  author={Rainer Malik and Ganesh Singh Chauhan and Matthew Traylor and Muralidharan Sargurupremraj and Yukinori Okada and Aniket Mishra and Loes Ca Rutten-Jacobs and A K Giese and Sander W van der Laan and S{\'o}lveig Gr{\'e}tarsd{\'o}ttir and C. D. P. Anderson and Michael Chong and Hieab H H Adams and Tetsuro Ago and Peter Almgren and Philippe Amouyel and Hakan Ay and Traci M Bartz and Oscar R. Benavente and Steve N Bevan and Giorgio Boncoraglio and Robert J Brown and Adam S. Butterworth and Caty A Carrera and Cara L. Carty and Daniel Chasman and Wei-Min Chen and John W. Cole and Adolfo Correa and Ioana Cotlarciuc and Carlos Cruchaga and John Danesh and Paul I W de Bakker and Anita L. DeStefano and Marcel den Hoed and Qing Duan and Stefan Thomas Engelter and Guido J Falcone and Rebecca F. Gottesman and Raji Paul Grewal and Vilmundur Gudnason and Stefan Gustafsson and Jeffrey Haessler and Tamara B. Harris and Ahamad Hassan and Aki S. Havulinna and Susan R. Heckbert and Elizabeth G. Holliday and George Howard and Fang-Chi Hsu and Hyacinth I Hyacinth and M. Arfan Ikram and Erik Ingelsson and Marguerite R. Irvin and Xueqiu Jian and Jordi Jim{\'e}nez-Conde and Julie A. Johnson and J Wouter Jukema and Masahiro Kanai and Keith L. Keene and Brett M Kissela and Dawn Kleindorfer and Charles L. Kooperberg and Michiaki Kubo and Leslie A. Lange and Carl D. Langefeld and Claudia Langenberg and Lenore J. Launer and Jin-Moo Lee and Robin Lemmens and Didier Leys and Cathryn M. Lewis and Wei-Yu Lin and Arne G. Lindgren and Erik Lorentzen and Patrik K E Magnusson and Jane Maguire and Ani Manichaikul and Patrick F. McArdle and James F Meschia and Braxton D. Mitchell and Thomas H. Mosley and Michael A. Nalls and Toshiharu Ninomiya and Martin J O'Donnell and Bruce M. Psaty and Sara L. Pulit and Kristiina Rannikm{\"a}e and Alex P. Reiner and Kathryn M. Rexrode and Kenneth Rice and Stephen S. Rich and Paul M. Ridker and Natalia S. Rost and Peter M. Rothwell and Jerome I. Rotter and Tatjana Rundek and Ralph L. Sacco and Saori Sakaue and Michele M Sale and Veikko V Salomaa and Bishwa Raj Sapkota and Reinhold Schmidt and Carsten Oliver Schmidt and Ulf Schminke and Pankaj Sharma and Agnieszka Julia Slowik and Cathie L. M. Sudlow and Christian Tanislav and Turgut Tatlisumak and Kent D. Taylor and Vincent Thijs and Gudmar Thorleifsson and Unnur Thorsteinsdottir and Steffen Tiedt and Stella Trompet and Christophe Tzourio and Cornelia M van Duijn and Matthew R. Walters and Nicholas J Wareham and Sylvia Wassertheil-Smoller and James G. Wilson and Kerri L Wiggins and Qiong Yang and Salim Yusuf and Joshua C Bis and Tomi Pastinen and Arno Ruusalepp and Eric E. Schadt and Simon Koplev and Johan Bj{\"o}rkegren and Veronica Codoni and Mete Civelek and Nicholas L. Smith and David A Tr{\'e}gou{\"e}t and Ingrid E Christophersen and Carolina Roselli and Steven A Lubitz and Patrick T Ellinor and E. Shyong Tai and Jaspal Singh Kooner and Norihiro Kato and Jiang He and Pim van der Harst and Paul Elliott and John Campbell Chambers and Fumihiko Takeuchi and Andrew D. Johnson and Dharambir Kaur Sanghera and Olle Melander and Christina Jern and D Strbian and Israel Fern{\'a}ndez-Cadenas and W. T. Longstreth and Arndt Rolfs and Jun Hata and Daniel Woo and Jonathan Rosand and Guillaume Par{\'e} and Jemma C. Hopewell and Danish Saleheen and K{\'a}ri Stef{\'a}nsson and Bradford Worrall and S J Kittner and Sudha Seshadri and Myriam Fornage and Hugh S. Markus and Joanna M M Howson and Yoichiro Kamatani and St{\'e}phanie Debette and Martin Dichgans and Najaf Amin and Hugo S Aparicio and Donna K Arnett and John R Attia and Alexa Beiser and C Berr and Julie E. Buring and Mariana Bustamante and Valeria Caso and Y C Cheng and Seung Hoan Choi and Ayesha Chowhan and Natalia Cullell and J F Dartigues and Hossein Delavaran and Pilar Delgado and Marcus D{\"o}rr and Gunnar Engstr{\"o}m and Ian Ford Ford and Wander S Gurpreet and Anders Hamsten and Laura E Heitsch and Atsushi Hozawa and Laura Iba{\~n}ez and Andreea Ilinca and Martin Ingelsson and Motoki Iwasaki and Rebecca D. Jackson and Katarina Jood and Pekka J Jousilahti and Sara Kaffashian and Lalit Kalra and Masahiro Kamouchi and Takanari Kitazono and Olafur Kjartansson and Manja Kloss and Peter J Koudstaal and Jerzy Krupinski and Daniel L. Labovitz and Cathy C. Laurie and Christopher Royce Levi and Linxin Li and Lars Lind and Cecilia M. Lindgren and Vasileios Lioutas and Yong Liu and Oscar L. Lopez and Hirata Makoto and N Martinez-Majander and Koichi Matsuda and Naoko Minegishi and J Montaner and Andrew P. Morris and Elena Mui{\~n}o and Martina M{\"u}ller-Nurasyid and Bo Norrving and Soichi Ogishima and Eugenio Agostino Parati and Leema Reddy Peddareddygari and Nancy L Pedersen and Joanna Pera and Markus Perola and Alessandro Pezzini and Silvana Pileggi and Raquel Rabionet and Iolanda Riba-Llena and Marta Ribas{\'e}s and Jos{\'e} Rafael Romero and J Roquer and Anthony G Rudd and Antti-Pekka Sarin and Ralhan Sarju and Chlo{\'e} Sarnowski and Makoto Sasaki and Claudia L Satizabal and Mamoru Satoh and Naveed Sattar and Norie Sawada and Gerli Sibolt and Asgeir Sigurdsson and Albert Vernon Smith and Kenji Sobue and Carolina Soriano-T{\'a}rraga and Tara M. Stanne and Oscar Colin Stine and David Stott and Konstantin Strauch and T. Takai and Hideo Tanaka and Kozo Tanno and Alexander Teumer and Liisa Tomppo and Ameeta Grover and Emmanuel Touz{\'e} and Shoichiro Tsugane and Andr{\'e} G. Uitterlinden and Einar M{\'a}r Valdimarsson and Sven J van der Lee and Henry V{\"o}lzke and Kenji Wakai and David R. Weir and Stephen C. R. Williams and Charles D A Wolfe and Quenna Wong and Huichun Xu and Taiki Yamaji},
  journal={Nature Genetics},
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage… CONTINUE READING
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