Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.

Abstract

Spontaneous activity in neuronal cultures on microelectrode arrays (MEAs) is sensitive to effects of drugs, chemicals, and particles. Multi-well MEA (mwMEA) systems have increased throughput of MEAs, enabling their use for chemical screening. The present experiments examined a subset of EPA's ToxCast compounds for effects on spontaneous neuronal activity in… (More)
DOI: 10.1016/j.neuro.2014.06.012

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@article{Valdivia2014MultiwellMA, title={Multi-well microelectrode array recordings detect neuroactivity of ToxCast compounds.}, author={Pablo Valdivia and M. Ballesteros Martin and William R Lefew and James F Ross and Keith Houck and Timothy J. Shafer}, journal={Neurotoxicology}, year={2014}, volume={44}, pages={204-17} }