Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats.

@article{Hsiao2011MultitissueSP,
  title={Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats.},
  author={Gene Hsiao and Justin Chapman and Jachelle M. Ofrecio and Jason Wilkes and Jamie L. Resnik and Divya Thapar and Shankar Subramaniam and Dorothy D Sears},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={300 1},
  pages={E164-74}
}
Peroxisome proliferator-activated receptor-γ (PPARγ) ligands, including the insulin-sensitizing thiazolidinedione drugs, transcriptionally regulate hundreds of genes. Little is known about the relationship between PPARγ ligand-specific modulation of cellular mechanisms and insulin sensitization. We characterized the insulin sensitivity and multitissue gene expression profiles of lean and insulin-resistant, obese Zucker rats untreated or treated with one of four PPARγ ligands (pioglitazone… CONTINUE READING
36 Citations
52 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 52 references

Polymorph and particle size control of PPAR compounds PF00287586 and AG035029

  • B Kline, J Saenz, N Stankovi, M. Mitchell
  • Org Process Res Devel
  • 2006
Highly Influential
7 Excerpts

Process development and scale-up of AG035029

  • J Saenz, M Mitchell, +6 authors K. Albizati
  • Org Process Res Devel
  • 2006
Highly Influential
7 Excerpts

SELECTIVE PPAR MODULATION IN OBESE RATS AJP-Endocrinol Metab

  • CB Newgard, J An, +15 authors RS Surwit
  • Jne 24,
  • 2011
2 Excerpts

Similar Papers

Loading similar papers…