Multi-targeting by monotherapeutic antibacterials

@article{Silver2007MultitargetingBM,
  title={Multi-targeting by monotherapeutic antibacterials},
  author={Lynn L. Silver},
  journal={Nature Reviews Drug Discovery},
  year={2007},
  volume={6},
  pages={41-55}
}
Antibacterial discovery research has been driven, medically, commercially and intellectually, by the need for new therapeutics that are not subject to the resistance mechanisms that have evolved to combat previous generations of antibacterial agents. This need has often been equated with the identification and exploitation of novel targets. But efforts towards discovery and development of inhibitors of novel targets have proved frustrating. It might be that the 'good old targets' are… CONTINUE READING

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