Multi-targeted therapy of cancer by omega-3 fatty acids-an update.
- Biology, MedicineCancer letters
Omega-3 and Omega-6 Fatty Acids and Breast Cancer
A high Ω-6/Ω-3 ratio, as is found in current Western diets, promotes the pathogenesis of many diseases, including cardiovascular disease, cancer, osteoporosis, arthritis, inflammatory and autoimmune diseases, whereas increased levels of Ω -3 PUFA, exert suppressive effects.
Omega-3 Fatty Acids for Prevention of Breast Cancer: an Update and the State of the Science
- MedicineCurrent Breast Cancer Reports
Several clinical trials are investigating strategies to favorably alter endogenous fatty acid profiles in an attempt to develop clinically feasible prevention methods, and identification of well-defined subpopulations who are most likely to benefit from a targeted prevention approach will probably be crucial to this effort.
Role of diets rich in omega-3 and omega-6 in the development of cancer.
- MedicineBoletin medico del Hospital Infantil de Mexico
n-3 Polyunsaturated Fatty Acids and Their Role in Cancer Chemoprevention
- Biology, MedicineCurrent Pharmacology Reports
This review of research shows n-3 PUFAs and their mediators can inhibit inflammation, angiogenesis, and cancer via multiple mechanisms, including reduced release of n-6 fatty acid arachidonic acid from cell membranes, inhibition of enzymatic activities, and direct competition with arachidsic conversions.
Role of omega-3 fatty acids in improving health.
- MedicineJPMA. The Journal of the Pakistan Medical Association
There is a gap in the knowledge and prescribing practices of physicians in Pakistan with regards to n-3 PUFAs in view of the recommended practice of prescription of these fatty acids by many Western health bodies.
Omega-3 polyunsaturated fatty acids and cancer: lessons learned from clinical trials
- Medicine, BiologyCancer and Metastasis Reviews
This review has collected the available clinical data on the therapeutic role of omega-3 FAs against breast cancer, colorectal cancer, leukemia, gastric cancer, pancreatic cancer, esophagealcancer, prostate cancer, lung cancer, head and neck cancer, as well as cancer cachexia.
ω-3 PUFAs: Interventional Trials for the Prevention and Treatment of Breast and Prostate Cancer
In this review, the objectives of ongoing and recently closed clinical trials of ω-3 PUFA supplements for breast and prostate cancer prevention and treatment that are listed in the ClinicalTrials.gov database are summarized.
Polyunsaturated Fatty Acid-Loaded Nanomedicine for Solid Tumor
The documented anticancer activities of omega-6 PUFAs are reviewed, together with the current results regarding the anticancer effects of free radical-mediated DGLA peroxidation.
Omega-3 Fatty Acids in Cancer Prevention and Control: A Membrane Perspective
It is demonstrated that dietary n-3 PUFA have utility in the prevention of cancer development through mechanisms centered at both the molecular, cellular, and tissue level.
SHOWING 1-10 OF 147 REFERENCES
Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer.
The importance of the ratio of omega-6/omega-3 essential fatty acids.
- MedicineBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids.
- Biology, MedicineThe Journal of clinical investigation
The data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis, highlighting the importance of gene-diet interactions in prostate cancer.
Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2.
- Medicine, BiologyClinical cancer research : an official journal of the American Association for Cancer Research
These results provide a sound basis for clinical trials evaluating the effect of dietary n-3 fatty acids from fish oil on tumor PGE(2) and membrane fatty acid composition, and serum and tumor biomarkers of progression in men with prostate cancer.
Colon cancer, fatty acids and anti-inflammatory compounds
- BiologyCurrent opinion in gastroenterology
This review focuses on recent studies which address three emerging mechanisms of n-3 polyunsaturated fatty acids action: metabolic interconversion into bioactive eicosanoids, modulation of nuclear receptor activation, and alteration of membrane phospholipid composition and functionality of lipid microdomains.
Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms.
- BiologyThe American journal of clinical nutrition
Several molecular mechanisms whereby n-3 fatty acids may modify the carcinogenic process have been proposed, and influences on transcription factor activity, gene expression, and signal transduction pathways; alteration of estrogen metabolism; increased or decreased production of free radicals and reactive oxygen species; and mechanisms involving insulin sensitivity and membrane fluidity are proposed.
n-3 fatty acids and the metabolic syndrome.
- BiologyThe American journal of clinical nutrition
The use of n-3 PUFAs should be considered in more global strategies including changes in lifestyle, such as adhering to a healthy Mediterranean type of diet and practicing regular physical exercise.
Omega‐3 fatty acids improve liver and pancreas function in postoperative cancer patients
- MedicineInternational journal of cancer
After major abdominal tumor surgery, FO supplementation improved liver and pancreas function, which might have contributed to the faster recovery of patients and showed a tendency to shorter ICU stay under omega‐3 PUFA treatment.
Effect of Altering Dietary ω-6/ω-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2, and Prostaglandin E2
- Medicine, BiologyClinical Cancer Research
These results provide a sound basis for clinical trials evaluating the effect of dietary n-3 fatty acids from fish oil on tumor PGE2 and membrane fatty acid composition, and serum and tumor biomarkers of progression in men with prostate cancer.
n-3 Fatty acids and lipid peroxidation in breast cancer inhibition
- BiologyBritish Journal of Nutrition
New evidence on biological mechanisms which may be involved in the inhibition of mammary carcinogenesis by long-chain n-3 FA is examined, focusing on an apoptotic effect by its lipid peroxidation products.