Multi-targeted effects of G4-aptamers and their antiproliferative activity against cancer cells.

Abstract

We selected and investigated nine G-quadruplex (G4)-forming aptamers originally designed against different proteins involved in the regulation of cellular proliferation (STAT3, nucleolin, TOP1, SP1, VEGF, and SHP-2) and considered to be potential anticancer agents. We showed that under physiological conditions all the aptamers form stable G4s of different… (More)
DOI: 10.1016/j.biochi.2017.11.020

Cite this paper

@article{Ogloblina2017MultitargetedEO, title={Multi-targeted effects of G4-aptamers and their antiproliferative activity against cancer cells.}, author={Anna M. Ogloblina and Alexandra N Khristich and Natalia Y Karpechenko and Svetlana E Semina and Gennady A. Belitsky and Nina G. Dolinnaya and Marianna G. Yakubovskaya}, journal={Biochimie}, year={2017} }