Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application.

@article{Millan2006MultitargetSF,
  title={Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application.},
  author={Mark J Millan},
  journal={Pharmacology \& therapeutics},
  year={2006},
  volume={110 2},
  pages={
          135-370
        }
}
  • M. Millan
  • Published 1 May 2006
  • Psychology, Biology
  • Pharmacology & therapeutics
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509 Citations
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References

SHOWING 1-10 OF 3,693 REFERENCES
The role of monoamines in the actions of established and "novel" antidepressant agents: a critical review.
  • M. Millan
  • Psychology, Biology
    European journal of pharmacology
  • 2004
From monoamines to genomic targets: a paradigm shift for drug discovery in depression
TLDR
The different phases of antidepressant drug discovery in the past, present and future are covered, and the challenges and opportunities for antidepressant research are commented on.
New insights into the mechanisms of antidepressant therapy.
Recent developments in the psychobiology and pharmacotherapy of depression: optimising existing treatments and novel approaches for the future
TLDR
A review of current pharmacotherapeutic options for major depressive disorder, current understanding of the neurobiology and pathogenesis of MDD, and a review of new and promising directions in pharmacological research will be provided.
The pharmacology of putative early-onset antidepressant strategies
  • P. Blier
  • Psychology, Biology
    European Neuropsychopharmacology
  • 2003
Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers
TLDR
The task of developing novel medications for bipolar disorder is truly daunting, and it is hopeful that understanding the mechanism of action of current mood stabilizers will ultimately lead clinical trials with more specific medications and thus better treatments those who suffer from this devastating illness.
Dual Monoamine Modulation for Improved Treatment of Major Depressive Disorder
TLDR
Clinical evidence suggests that a number of novel antidepressant drugs, including mirtazapine, milnacipran, venlafaxine, and duloxetine have been developed and may offer improved efficacy and/or faster onset of action compared with SSRIs and an improved side effect profile compared with TCAs.
G protein signaling and the molecular basis of antidepressant action.
Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders.
Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders
...
...