Multi-step surface functionalization of polyimide based evanescent wave photonic biosensors and application for DNA hybridization by Mach-Zehnder interferometer.

@article{Melnik2011MultistepSF,
  title={Multi-step surface functionalization of polyimide based evanescent wave photonic biosensors and application for DNA hybridization by Mach-Zehnder interferometer.},
  author={E. I. Melnik and Roman Bruck and Rainer Hainberger and Michael L{\"a}mmerhofer},
  journal={Analytica chimica acta},
  year={2011},
  volume={699 2},
  pages={206-15}
}
The process of surface functionalization involving silanization, biotinylation and streptavidin bonding as platform for biospecific ligand immobilization was optimized for thin film polyimide spin-coated silicon wafers, of which the polyimide film serves as a wave guiding layer in evanescent wave photonic biosensors. This type of optical sensors make great demands on the materials involved as well as on the layer properties, such as the optical quality, the layer thickness and the surface… CONTINUE READING