Multi-step loading of human minichromosome maintenance proteins in live human cells.

@article{Symeonidou2013MultistepLO,
  title={Multi-step loading of human minichromosome maintenance proteins in live human cells.},
  author={Ioanna-Eleni Symeonidou and Panagiotis Kotsantis and Vassilis Roukos and Maria-Anna Rapsomaniki and Hern{\'a}n E. Grecco and Philippe I H Bastiaens and Stavros L. Taraviras and Zoi Lygerou},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 50},
  pages={35852-67}
}
Once-per-cell cycle replication is regulated through the assembly onto chromatin of multisubunit protein complexes that license DNA for a further round of replication. Licensing consists of the loading of the hexameric MCM2-7 complex onto chromatin during G1 phase and is dependent on the licensing factor Cdt1. In vitro experiments have suggested a two-step binding mode for minichromosome maintenance (MCM) proteins, with transient initial interactions converted to stable chromatin loading. Here… CONTINUE READING
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