Multi-step activation of NF-kappa B/Rel transcription factors.

  title={Multi-step activation of NF-kappa B/Rel transcription factors.},
  author={Michael Schmitz and Patrick A. Baeuerle},
  volume={193 2-4},
Transcription factors belonging to the NF-kappa B/Rel family are specialized in the transduction of primarily pathogenic signals from the cytoplasm to the cell nucleus. To date, the family comprises five distinct DNA-binding subunits and five regulatory proteins with inhibitory function, called I kappa B proteins. The interaction of dimers of the DNA-binding subunits with the I kappa B proteins leads to the cytoplasmatic retention of the complex and inhibition of its DNA binding. Following… CONTINUE READING

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