Multi-stage carcinogenesis in the urinary bladder.

@article{Cohen1985MultistageCI,
  title={Multi-stage carcinogenesis in the urinary bladder.},
  author={Samuel M Cohen},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1985},
  volume={23 4-5},
  pages={521-8}
}
  • Samuel M Cohen
  • Published 1985 in
    Food and chemical toxicology : an international…
Sodium saccharin has been shown to be a promoting substance for urinary bladder carcinogenesis in the rat following initiation with N-methyl-N-nitrosourea, N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT), or N-butyl-N-(4-hydroxybutyl)nitrosamine. It has been shown to have many of the properties of promoting substances in other animal models, such as the mouse skin; it lacks mutagenic activity, induces hyperplasia in the target tissue, and does not bind DNA. It has recently been… CONTINUE READING

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