Multi-source inputs converge on the superior salivatory nucleus neurons in anaesthetized rats

  title={Multi-source inputs converge on the superior salivatory nucleus neurons in anaesthetized rats},
  author={K. Ishizuka and Diana Oskutyte and Yoshihide Satoh and Toshiki Murakami},
  journal={Autonomic Neuroscience},
Activation of parasympathetic nerves innervating salivary glands evokes not only salivation but also vascular responses. These parasympathetic nerves may have cardiac and/or respiratory-related activity as well as the cardiovascular sympathetic nerves that control vascular bed of salivary glands. Therefore, we investigated whether preganglionic superior salivatory nucleus (SSN) neurons projecting to the submandibular and intra-lingual ganglia exhibit pulse-related and/or respiratory-related… Expand
The rostral parvicellular reticular formation neurons mediate lingual nerve input to the rostral ventrolateral medulla
It is concluded that the lingual trigeminal input exerts excitatory and/or inhibitory effects on a majority of the RVLM-projecting rRFp neurons, and their neuronal activity may be involved in the cardiovascular responses accompanied by the defense reaction. Expand
The physiology of salivary secretion.
Salivary films are essential for maintaining oral health and regulating the oral microbiome, and understanding the mechanisms by which components enter saliva is an important aspect of validating their use as biomarkers of health and disease. Expand
Salivary secretion: mechanism and neural regulation.
Continued advances in the understanding of the nerve-mediated regulation of salivary glands should help in the development of strategies for preventing chronic oral dryness resulting from drugs or atrophic disease associated with inflammation and irradiation. Expand
Interactions between developing nerves and salivary glands
This work will provide a brief overview of the neuroanatomy of the salivary glands and discuss recent literature that begins to integrate neurobiology with epithelial organogenesis, which may provide paradigms for exploring these interactions in other organ systems. Expand
Medication-Induced Dry Mouth
MIX in older age groups is associated with the number of medications being taken and is higher than seen in the younger subjects, and antihypertensive drugs that stimulate these receptors such as clonidine cause MIX and MISGD. Expand
Anatomy, biogenesis and regeneration of salivary glands.
The anatomy and biogenesis of the major human salivary glands and the rodent submandibular gland are discussed and a review of recent research suggests that nerves play an instructive role during development and may be essential for adult gland repair and regeneration is included. Expand
Application of Developmental Principles for Functional Regeneration of Salivary Glands
The goal of this review is to provide hypothesis for the further researches about differentiation of specific acinar cells, from which it is determined to be specific acini, and approaches to regenerate the function of salivary glands using environmental factor, time dependent factor and nerve factor. Expand
Salivary flow rate and the risk of cognitive impairment among Korean elders: a cross-sectional study
Salivary flow rate is independently associated with cognitive impairment among Korean elders and the association was modified in females and dentate elders. Expand
Proposal for research and education: joint lectures and practicals on central nervous system anatomy and physiology
The overall impression was that the practice of joint central nervous system lectures and practicals was an efficient method for students, which suggests that joint lectures might also be useful for clinical subjects. Expand


Gustatory-salivary reflex: neural activity of sympathetic and parasympathetic fibers innervating the submandibular gland of the hamster.
Deafferentation experiments suggest that the parasympathetic activity is mainly influenced by gustatory information via the chorda tympani, while the sympathetic activity can be evoked by both the chord a tympANI and glossopharyngeal nerve. Expand
Studies on neural mechanisms of the gustatory‐salivary reflex in rabbits.
It was found by the same procedure for the preganglionic fibres that sucrose and NaCl, and HCl and quinine produced a similar response profile, respectively, which means that the afferent taste inputs are processed into appropriate outputs in the lower brain stem without involvement of higher central nervous mechanisms. Expand
Analysis of reflex responses in preganglionic parasympathetic fibres innervating submandibular glands of rabbits.
The volume of reflex submandibular salivation evoked by varying frequencies of electrical shocks applied to the oral region correlated statistically significantly with the magnitude of responses in E‐ type fibres, which strongly suggests that E‐type fibres are secretory fibres. Expand
Cortically evoked responses of superior salivary nucleus neurons in the cat.
  • K. Ishizuka, T. Murakami
  • Medicine
  • Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran toimituksia
  • 1989
The excitatory inputs converging from the cerebral cortex and the lingual nerve, found in 63% of SSN neurons, could play an important role in submandibular and sublingual salivation. Expand
Ionotropic NMDA receptor evokes an excitatory response in superior salivatory nucleus neurons in anaesthetized rats
Activation of ionotropic NMDA receptors exerts an excitatory effect on about half of the SSN neurons, which support the view thatNMDA receptors are involved in information processing and transmission on SSn neurons. Expand
Subgroups of rostral ventrolateral medullary and caudal medullary raphe neurons based on patterns of relationship to sympathetic nerve discharge and axonal projections.
The data demonstrate that a substantial proportion of RVLM neurons and a small group of CMR neurons with activity correlated to SND do not project to the thoracic spinal cord and support the hypothesis that the outputs of the cardiac-related and 10-Hz rhythm generators converge on RVLM and CMR bulbospinal neurons rather than on their antecedent interneurons. Expand
Classification of caudal ventrolateral pontine neurons with sympathetic nerve-related activity.
The data demonstrate for the first time that there is a direct pathway from the CVLP to the IML that is comprised almost exclusively of sympathoexcitatory neurons whose discharges are correlated to both the 10-Hz and cardiac-related rhythms in SND. Expand
Lateral hypothalamic modulation of the gustatory-salivary reflex in rats
  • R. Matsuo, K. Kusano
  • Biology, Medicine
  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1984
The results of this study demonstrate that the LHA enhances the activity of the gustatory-salivary reflex in the lower brainstem. Expand
Neural substrates for reflex salivation induced by taste, mechanical, and thermal stimulation of the oral region in decerebrate rats.
The results suggest that two distinct neural pathways exist which mediate reflex salivation in the lower brain stem of the rat, i.e., the taste pathway via the NTS and the nociceptive pathway through the trigeminal sensory nuclei. Expand
Reflex responses of single salivatory neurons to stimulation of trigeminal sensory branches in the cat
Impulses of both A beta and A delta afferent fibres of the trigeminal nerve were found to be effective for activation of salivatory neurons. Expand