Multi-scale Modeling of Drug Action in the Nervous System

  title={Multi-scale Modeling of Drug Action in the Nervous System},
  author={Hugo Geerts and Patrick D. Roberts and Athan Spiros and Robert Carr},
Drug discovery and development in CNS diseases has one of the greatest failure rates of all indications. This is due to poor translation ability of preclinical animal models for diseases like schizophrenia, Alzheimer’s disease, and depression. In addition, treatment of patients in real-life situations is far from perfect, and polypharmacy is attempted without a rational understanding of the interactions of the various drugs with each other and with the brain circuits. A possible alternative is… CONTINUE READING


Publications citing this paper.