Multi-response model for rheumatoid arthritis based on delay differential equations in collagen-induced arthritic mice treated with an anti-GM-CSF antibody

@article{Koch2011MultiresponseMF,
  title={Multi-response model for rheumatoid arthritis based on delay differential equations in collagen-induced arthritic mice treated with an anti-GM-CSF antibody},
  author={Gilbert Koch and Thomas Gregor Wagner and Christine Plater-Zyberk and Gezim Lahu and Johannes Schropp},
  journal={Journal of Pharmacokinetics and Pharmacodynamics},
  year={2011},
  volume={39},
  pages={55-65}
}
Collagen-induced arthritis (CIA) in mice is an experimental model for rheumatoid arthritis, a human chronic inflammatory destructive disease. The therapeutic effect of neutralizing the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) by an antibody was examined in the mouse disease in a view of deriving a pharmacokinetic/pharmacodynamic (PKPD) model. In CIA mice the development of disease is measured by a total arthritic score (TAS) and an ankylosis score (AKS). We present a… CONTINUE READING
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