Multi-protein complexes in eukaryotic gene transcription

@article{Martinez2004MultiproteinCI,
  title={Multi-protein complexes in eukaryotic gene transcription},
  author={E. Martinez},
  journal={Plant Molecular Biology},
  year={2004},
  volume={50},
  pages={925-947}
}
  • E. Martinez
  • Published 2004
  • Biology, Medicine
  • Plant Molecular Biology
Specific transcription initiation by RNA polymerase II at eukaryotic protein-coding genes involves the cooperative assembly at the core promoter of more than 40 distinct proteins – with a total mass of over 2 MDa – including RNA polymerase II itself and general/basal transcription initiation factors, to form a stable pre-initiation complex (PIC). In vivo, PIC assembly is a major point of regulation by sequence-specific transcription regulators (activators and repressors) and is hindered by the… Expand
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